Cold Chemical Lamination—New Bonding Technique of LTCC Green Tapes

The low-temperature co-fired ceramic (LTCC) technology enables fabrication of sensors, actuators, microfludic devices² and fuel cells. The structures consist of screen-printed components, gas/liquid channels, reactive chambers and mixers. The lamination process determines the quality of such devices. Thermo-compression is the most popular bonding method. The LTCC green tapes are joined together at high temperature (up to 80°C) and high pressure (up to 30 MPa) for 2 to 15 minutes. The method allows good encapsulation of the LTCC structures, but the channels geometry is strongly affected by elevated temperature and pressure. Cold Chemical Lamination (CCL) is a new LTCC green tapes bonding technique, which allows for fabrication of 3D modules. A solvent-based method is used in the CCL lamination instead of the thermo-compression process. A special liquid agent is screen-printed on the green tape in the CCL method. The liquid melts the tape surface. Then the tapes are stacked and compressed at room temperature by a printing roll. The influence of the CCL and the thermo-compression methods on the chamber's geometry quality as well as basic electrical properties of screen-printed resistors (sheet resistance R_φ standard deviation of sheet resistance σ_R, variability coefficient of sheet resistance V_R, and long-term stability) are analyzed and compared in this paper. The bonding quality is examined by a scanning electron microscope (SEM).     

Synthesis and Biological Testing of N‐Aminoimidazole‐Based p38α MAP Kinase Inhibitors

The p38 mitogen‐activated protein (MAP) kinase α plays a central role in the regulation of cellular responses such as differentiation, proliferation, apoptosis, and inflammation. Inhibition of p38 results in decreased synthesis of pro‐inflammatory cytokines. To date, diverse p38α inhibitors are in phase II clinical trials for numerous cytokine‐dependent diseases. 2‐Sulfanylimidazole derivatives offer advantages over the prototype inhibitor SB 203580, including fewer cytochrome P450 interactions and better kinetic properties. The aim of this study was to develop novel 1,2,4,5‐tetrasubstituted pyridinylimidazoles with acyl residues at the imidazole N1 position that can interact with the kinase's hydrophobic region II (HR II) or sugar pocket (SP) to improve both selectivity and activity. The substitution pattern was optimized by variation of the acyl moiety at the N1 position of the N‐aminoimidazole core. Acylation of the amino function was used for optimization and led to potent p38α MAPK inhibitors.     

Low-pressure,thermo-compressive lamination

Lamination of green ceramic tapes is one of the most important technological processes in multilayer ceramic technology. Lamination affects the quality of all 3D structures (e.g., channels, chambers, membranes, etc.). Novel chemical methods of lamination reduce the deformation of 3D structures. However, these methods are useless in the fabrication of thin membranes and structures with thick-film electronic components or electric vias. Therefore, thermo-compressive lamination is still the best solution for the lamination of green ceramic tapes. Low-pressure thermo-compressive lamination with an insert material is presented in this paper. The influence of pressure and Low Temperature Cofired Ceramics (LTCC) material on the compressibility and shrinkage of LTCC, as well as the influence of the insert material on deflection and distortion of the membranes are presented and discussed in this paper.     

APPLICATION OF CONCENTRATED SOLAR RADIATION TO HIGH TEMPERATURE DETOXIFICATION AND RECYCLING PROCESSES OF HAZARDOUS WASTES

In many cases, hazardous wastes are subject to thermal treatment at elevated temperatures. Some types of wastes do not have a sufficient calorific value to cover the heat demand of the high temperature process. For thermal treatment of e.g. filter residues, dusts, sulfuric acid, aluminium dross, foundry sand, or waste water, supplementary energy supply is needed. The specific energy demand ranges from 0.5 to 2.5 kWh/kg (2–10 MJ/kg). An important aim of process optimisation is the reduction of (fossil) energy consumption and exhaust gas flow. Concentrated solar energy promises advantages when applied to high energy consuming waste treatment processes with regard to substitute fossil or electric energy consumption, to reduce CO₂ emissions, and exhaust gas flow. In parallel to conceptional studies, a solar-heated rotary kiln mini-plant has been designed and constructed for tests in the DLR solar furnace. The tests will give indications of boundary conditions for solar thermal treatment or conversion of selected hazardous materials.     

Ionic Space‐Charge Depletion in Lithium Fluoride Thin Films on Sapphire (0001) Substrates

Lithium fluoride thin films with various thicknesses have been grown on c‐plane sapphire substrates by radio‐frequency sputtering. The thin films are granular with a preferential [111] orientation of the grains. Thickness‐dependent measurements allow the separation of bulk and interface conductions. The normalized conductance decreases linearly with decreasing LiF layer thickness with a negative extrapolated intercept. DC polarization, AC impedance spectroscopy and electromotive force measurement indicate depletion of lithium ion vacancies as majority charge carriers and hence a negative space‐charge potential. A generalized Mott–Schottky approach within the model of heterogeneous doping fully explains the entire boundary defect chemistry.     

Rezente Mängel der Leichenschau und ihre historischen Ursachen: Eine Analyse aus medizingeschichtlicher Sicht

In recent years, the enactment of uniform national regulations concerning postmortem examination has become a persistent demand. There is strong criticism of the reliability of coroner's inquest: The education of most of the coroners in forensic medicine is found to be insufficient, and many experts report that medical examiners partly are neglectful for the inquest. The classification of the manner of death is also said to be deficient, the rate of misdiagnosis being only little below 50 %. Thus much emphasis is put on demanding a reinforced training of doctors in the field of the external examination of corpses. But only few of those reports make allowance for the fact that that most of the present deficiencies have their origin in the 19th century. As a matter of fact, from the outset the practise of coroner's inquest gave rise to criticism. Thus the present article traces the historical roots of postmortem examination in Germany. Special emphasis is placed on a comparison between the infancies of coroner's inquest and the current state. Actual and historical imperfections in the system of postmortem examination and striking similarities are pointed out.      

Physical modeling and control of dynamic foaming in an LD-converterprocess

This paper deals with physical modeling and control of dynamic foaming in the LD-converter process. An experimental setup consisting of a water model, digital signal processor, and PC hardware is built and shown to be useful for studying dynamic foaming. Furthermore, a foam height estimation algorithm is presented and validated through experiments. Finally, sound signals from the LD-converter and water model are compared and similarities between them are found     

Antireflection coated, wedged, single-crystal silicon aircraftwindow for the far-infrared

Operating far-infrared remote-sensing instruments from inside a pressurized cabin of an aircraft requires a window with high transmittance. Furthermore, the radiometric properties of the window, such as the transmittance and the emitted radiation (i.e., temperature distribution), have to be known. The design of a wedged, antireflection coated single-crystal silicon aircraft window, its modeled transmittance spectrum, and the applied coating technique are presented. Measurements of the window transmittance with the 2.5 THz heterodyne spectrometer TeraHertz OH-Measurement Airborne Sounder (THOMAS) and a Fourier-transform spectrometer are presented, showing a transmittance of about 90% around 84 cm^-1. The window was designed and built for the 2.5 THz OH-Sensor THOMAS, operated on the DLR research aircraft FALCON. The transmittance of 90% means a substantial improvement compared to the window used previously. With this new window, systematic errors in the measured atmospheric radiance could be lowered, making the retrieval of atmospheric parameters easier. Several successful flights with the new window up to an altitude of 43000 ft have already been performed     

Simulation of Flow and Mass Transport in a Meander Microchannel Subject to Electroosmotic Pumping

We have investigated the flow and mass transport within an electroosmotically pumped incompressible liquid through a meander microchannel system. We employ two-dimensional, time-dependent finite element simulations in conjunction with a matched asymptotic treatment of the electrical double layers. The electroosmotic pumping is realized for two idealized and two realistic electrical fields, while a pressure-driven flow is used for comparison. We focus on the aspects of the electroosmotic transport.

We find for most of the electroosmotically driven cases rather complex flow fields, involving recirculation regions. These recirculation regions in all cases increase dispersion. (i) The least dispersion is associated with a plug-type velocity profile, which is obtained for an idealized purely wall-tangential orientation of the electrical field. (ii, iii) We find that both the idealized horizontal electrical field and the real electrical field between two vertical plates give considerably higher dispersion than the pressure-driven flow. Vertical plate electrodes, therefore, do not allow for a electrical field, which minimizes dispersion. (iv) The arrangement of two point electrodes at the in and out sections likewise proves to be no optimal means to reduce dispersion beyond the pressure-driven flow. Thus, meander geometries of channels, in general, cause severe problems if electroosmotic pumping needs to be achieved in combination with minimized dispersion.